Niemann-Pick disease is a group of inherited metabolic disorders, which has a higher incidence among people with Ashkenazi Jews ancestry.
Research has found an estimate of one in 40,000 for type A of Niemann–Pick disease for Ashkenazi Jews, while the incidence of both Niemann–Pick disease types A and B in all other populations is estimated to be one in 250,000. [1]
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[1] "Neimann-Pick Disease". Genetics Home Reference. NIH. January 2008.